35048-47-6
35048-47-6 structure
- Name: β-Estradiol-6-one 6-(O-carboxymethyloxime)
- Chemical Name: 17β-estradiol 6-O-(carboxymethyl)oxime
- CAS Number: 35048-47-6
- Molecular Formula: C20H25NO5
- Molecular Weight: 359.416
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-08-21 21:49:05
- Modify Date: 2024-01-02 12:36:21
-
β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 17β-estradiol 6-O-(carboxymethyl)oxime |
|---|---|
| Synonyms |
((((17β)-3,17-Dihydroxyestra-1,3,5(10)-trien-6-ylidene)amino)oxy)acetic acid
Beta-Estradiol-6-one 6-(O-carboxymethyloxime) Acetic acid, 2-[[[(6E,17β)-3,17-dihydroxyestra-1(10),2,4-trien-6-ylidene]amino]oxy]- 17β-estradiol 6-O-(carboxymethyl)oxime 1,3,5[10]-ESTRATRIENE-3,17-DIOL-6-ONE 6-[O-CARBOXYMETHYL]OXIME 17beta-estradiol 6-O-(carboxymethyl)oxime β-Estradiol-6-one 6-(O-carboxymethyloxime) SS-ESTRADIOL-6-ONE 6-(O-CARBOXYMETHYLOXIME) 6-keto-1,3,5(10)estratriene-3,17β-diol 6-carboxymethyloxime ({(E)-[(6E,17β)-3,17-Dihydroxyestra-1(10),2,4-trien-6-ylidene]amino}oxy)acetic acid |
| Description | β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 572.6±60.0 °C at 760 mmHg |
| Molecular Formula | C20H25NO5 |
| Molecular Weight | 359.416 |
| Flash Point | 300.1±32.9 °C |
| Exact Mass | 359.173279 |
| PSA | 99.35000 |
| LogP | 2.31 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.680 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
|
~%
35048-47-6 |
| Literature: Steroids, , vol. 19, # 4 p. 509 - 518 |
|
~%
35048-47-6 |
| Literature: Steroids, , vol. 18, p. 593 - 603 |
|
~%
35048-47-6 |
| Literature: Steroids, , vol. 18, p. 593 - 603 |
|
~%
35048-47-6 |
| Literature: Steroids, , vol. 30, # 1 p. 85 - 98 |
|
~%
35048-47-6 |
| Literature: Steroids, , vol. 21, p. 259 - 283 |
|
~%
35048-47-6 |
| Literature: Steroids, , vol. 21, p. 259 - 283 |
| Precursor 6 | |
|---|---|
| DownStream 0 | |