786686-79-1

786686-79-1 structure

Name: Olanzapine D3
Chemical Name: 2-methyl-4-[4-(trideuteriomethyl)piperazin-1-yl]-5H-thieno[3,2-c][1,5]benzodiazepine
CAS Number: 786686-79-1
Molecular Formula: C₁₇H₁₇D₃N₄S
Molecular Weight: 315.45100
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-12 00:11:17
Modify Date: 2024-01-31 11:27:59
Olanzapine D3 (LY170053 D3) is the deuterium labeled Olanzapine. Olanzapine is 5-HT2 and D1/D2 antagonist. Olanzapine is an antipsychotic agent with anticholinergic properties[1]. Olanzapine induces autophagy, mitochondrial damage and mitophagy in human SH-SY5Y neuronal cell line[2].

Name	2-methyl-4-[4-(trideuteriomethyl)piperazin-1-yl]-5H-thieno[3,2-c][1,5]benzodiazepine
Synonyms	Olanzapine-methyl-d3 2-methyl-4-(4-methyl-D3-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine Oliza-d3 Oltal-d3 Integrol-d3 Zyprexa-d3 Olanzapine-d3 Oleanz-d3 Lanzac-d3

Description	Olanzapine D3 (LY170053 D3) is the deuterium labeled Olanzapine. Olanzapine is 5-HT2 and D1/D2 antagonist. Olanzapine is an antipsychotic agent with anticholinergic properties[1]. Olanzapine induces autophagy, mitochondrial damage and mitophagy in human SH-SY5Y neuronal cell line[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Moore NA, et al. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J Pharmacol Exp Ther. 1992 Aug;262(2):545-51. [2]. Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.