86426-17-7

86426-17-7 structure

Name: Mildronate
Chemical Name: Mildronate dihydrate
CAS Number: 86426-17-7
Molecular Formula: C₆H₁₈N₂O₄
Molecular Weight: 182.218
Catalog: Biochemical Inhibitor Metabolism Hydroxylase inhibitor
Create Date: 2018-09-30 17:47:24
Modify Date: 2024-01-11 11:46:53
Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1].

Name	Mildronate dihydrate
Synonyms	3-(2,2,2-Trimethylhydrazinium)propionate dihydrate Diazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt, hydrate (1:2) Mildronatedehydrate 3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate dihydrate Mildronate

Description	Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2).
References	[1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport