Mildronate

Modify Date: 2024-01-11 11:46:53

Mildronate Structure
Mildronate structure
Common Name Mildronate
CAS Number 86426-17-7 Molecular Weight 182.218
Density N/A Boiling Point N/A
Molecular Formula C6H18N2O4 Melting Point N/A
MSDS Chinese Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Mildronate


Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1].

 Names

Name Mildronate dihydrate
Synonym More Synonyms

 Mildronate Biological Activity

Description Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1].
Related Catalog
Target

IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2).

References

[1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780.

[2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25.

 Chemical & Physical Properties

Molecular Formula C6H18N2O4
Molecular Weight 182.218
Exact Mass 182.126663
PSA 70.62000
Appearance of Characters white to off-white
Storage condition 2-8°C
Water Solubility H2O: >40mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport

 Articles1

More Articles
A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application.

J. AOAC Int. 97(6) , 1526-37, (2015)

A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs we...

 Synonyms

3-(2,2,2-Trimethylhydrazinium)propionate dihydrate
Diazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt, hydrate (1:2)
Mildronatedehydrate
3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate dihydrate
Mildronate
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