20229-56-5

20229-56-5 structure

Name: spiraeoside
Chemical Name: quercetin 4ʼ-O-β-D-glucopyranoside
CAS Number: 20229-56-5
Molecular Formula: C₂₁H₂₀O₁₂
Molecular Weight: 464.37600
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-07-18 16:16:09
Modify Date: 2024-01-02 09:09:38
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].

Name	quercetin 4ʼ-O-β-D-glucopyranoside
Synonyms	Spiraeosid Quercetin 4'-b-D-glucopyranoside Quercetin 4'-O-glucoside Quercetin-4'-glucoside EINECS 243-614-6 Spiraein 3,5,7-trihydroxy-2-[3-hydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one quercetin 4'-O-beta-D-glucopyranoside Spiraeoside

Description	Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology
In Vitro	Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversedby LY294002)[1]. Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis[1]. Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG[1]. Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway[1]. Cell Viability Assay[1] Cell Line: AC16 cells. Concentration: 1, 5, 10, or 20 μM. Incubation Time: 0, 24, or 48 hours. Result: Inhibited AC16 cells viability (20 μM).
In Vivo	Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability[2]. Animal Model: Male Wistar rats (6-8 weeks old)[2]. Dosage: 50 mg/kg. Administration: Oral gavage an hour before inducing the lesions. Result: Decreased severity of the formed lesions.
References	[1]. Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22548. [2]. Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.

Density	1.809g/cm3
Boiling Point	835.6ºC at 760mmHg
Melting Point	209-211ºC
Molecular Formula	C₂₁H₂₀O₁₂
Molecular Weight	464.37600
Flash Point	294.6ºC
Exact Mass	464.09500
PSA	210.51000
Vapour Pressure	1.28E-29mmHg at 25°C
Index of Refraction	1.774
Storage condition	?20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3095000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)-3-hydroxyphenyl)-3,5, 7-trihydroxy-

CAS REGISTRY NUMBER :: 20229-56-5

LAST UPDATED :: 199503

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-C12

MOLECULAR WEIGHT :: 416.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport

Precursor 6
1313191-85-3 117-39-5 572-09-8 1313191-83-1
357194-03-7 133-89-1
DownStream 2
2280-44-6 117-39-5

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