Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Piribedil
Price: ￥198.0/1g ￥108.0/250mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Piribedil
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

3605-01-4

3605-01-4 structure

Name: Piribedil
Chemical Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
CAS Number: 3605-01-4
Molecular Formula: C₁₆H₁₈N₄O₂
Molecular Weight: 298.340
Catalog: API Nervous system medication Anti-shock palsy
Create Date: 2018-06-07 11:20:29
Modify Date: 2024-01-02 14:33:28
Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR).

Name	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Synonyms	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)- 2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine Piribedilum [INN-Latin] 1-(2''-Pyrimidyl)-4-(methylene-3',4'-dioxybenzyl)piperazine 2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine Piribedile [DCIT] 3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine Piribedil ET 495 Trivastal MFCD00868264 Trivastan Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]- EU-4200 EINECS 222-764-6 2-[4-(3,4-Methylenedioxybenzyl)piperazino]pyrimidine

Description	Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2R, hα1A-AR[1]
References	[1]. Mark J. Milla, et al. Antiparkinsonian Agent Piribedil Displays Antagonist Properties at Native, Rat, and Cloned, Human α2 -Adrenoceptors: Cellular and Functional Characterization. JPET, 2001, 297 (3) 876-887.

Density	1.3±0.1 g/cm3
Boiling Point	469.4±55.0 °C at 760 mmHg
Melting Point	98 °C
Molecular Formula	C₁₆H₁₈N₄O₂
Molecular Weight	298.340
Flash Point	237.7±31.5 °C
Exact Mass	298.142975
PSA	50.72000
LogP	2.36
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.632
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9704000

CHEMICAL NAME :: Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 3605-01-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H18-N4-O2

MOLECULAR WEIGHT :: 298.38

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1- AT6N DNTJ D- BT6N CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 6,75,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Vascular - regional or general arteriolar or venous dilation Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,1151,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 6,75,1969

Hazard Codes	Xi
HS Code	2934999090

495-76-1

20980-22-7

~99%

3605-01-4

Literature: Peishan, Siah; Dang, Tuan Thanh; Seayad, Abdul Majeed; Ramalingam, Balamurugan ChemCatChem, 2014 , vol. 6, # 3 p. 808 - 814

120-57-0

20980-22-7

~74%

3605-01-4

Literature: Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R. Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552

120-57-0

20980-22-7

~54%

88268-16-0

3605-01-4

Literature: Chilmonczyk; Cybulski; Krajewski; Szelejewski Archiv der Pharmazie, 1993 , vol. 326, # 4 p. 241 - 242

64-18-6

20980-22-7

~54%

88268-16-0

3605-01-4

Literature: Chilmonczyk; Cybulski; Krajewski; Szelejewski Archiv der Pharmazie, 1993 , vol. 326, # 4 p. 241 - 242

780705-64-8

3605-01-4

Literature: Tetrahedron Letters, , vol. 47, # 15 p. 2549 - 2552

Precursor 5
495-76-1 20980-22-7 120-57-0 64-18-6
780705-64-8
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3605-01-4	1398044-45-5
53954-71-5	52293-23-9
1022849-90-6	78213-63-5