322-79-2
322-79-2 structure
- Name: Triflusal
- Chemical Name: 2-acetyloxy-4-(trifluoromethyl)benzoic acid
- CAS Number: 322-79-2
- Molecular Formula: C10H7F3O4
- Molecular Weight: 248.155
- Catalog: Biochemical Inhibitor Neuronal Signaling COX inhibitor
- Create Date: 2018-03-27 08:00:00
- Modify Date: 2024-01-04 06:27:34
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Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.Target: COXTriflusal at 10 mM, 100 mM and 1 M decreases LDH efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively. Triflusal also reduces inducible NO synthase activity by 18%, 21% and 30% [1].Triflusal (10 mg/kg i.v.) reduces platelet deposition on subendothelium-induced primary thrombus by about 68% in rabbits. Triflusal (10 mg/kg i.v.) reduces platelet deposition on a fresh thrombus formed over tunica media by about 48% in rabbits. Triflusal (40 mg/kg p.o.) reduces platelet deposition on a primary thrombus triggered by subendothelium and tunica media by 53% in rabbits. Triflusal (40 mg/kg p.o.) significantly reduces Cox-2 mRNA levels and protein levels without influence Cox-1 mRNA levels on the vascular wall in rabbits [2]. Triflusal (600 mg/day for 5 days) results in an increase in NO production by neutrophils and an increase in endothelial nitric oxide synthase (eNOS) protein expression in neutrophils in healthy volunteers [3].
| Name | 2-acetyloxy-4-(trifluoromethyl)benzoic acid |
|---|---|
| Synonyms |
Triflusal
2-(acetyloxy)-4-(trifluoromethyl)benzoic acid α,α,α-Trifluoro-2,4-cresotic Acid Acetate 2-Acetoxy-4-trifluoromethylbenzoic acid EINECS 206-297-5 Triflusalum [INN-Latin] 2-Acetoxy-4-trifluoromethylbenzoicacid Benzoic acid, 2-(acetyloxy)-4-(trifluoromethyl)- Triflusal [INN] 2-Acetoxy-4-trifluormethyl-benzoesaeure 2-Acetoxy-4-(trifluoromethyl)benzoic acid 2-Acetyloxy-4-trifluoromethylbenzoic acid UR 1501 MFCD00866793 Disgren Triflux |
| Description | Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.Target: COXTriflusal at 10 mM, 100 mM and 1 M decreases LDH efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively. Triflusal also reduces inducible NO synthase activity by 18%, 21% and 30% [1].Triflusal (10 mg/kg i.v.) reduces platelet deposition on subendothelium-induced primary thrombus by about 68% in rabbits. Triflusal (10 mg/kg i.v.) reduces platelet deposition on a fresh thrombus formed over tunica media by about 48% in rabbits. Triflusal (40 mg/kg p.o.) reduces platelet deposition on a primary thrombus triggered by subendothelium and tunica media by 53% in rabbits. Triflusal (40 mg/kg p.o.) significantly reduces Cox-2 mRNA levels and protein levels without influence Cox-1 mRNA levels on the vascular wall in rabbits [2]. Triflusal (600 mg/day for 5 days) results in an increase in NO production by neutrophils and an increase in endothelial nitric oxide synthase (eNOS) protein expression in neutrophils in healthy volunteers [3]. |
|---|---|
| Related Catalog | |
| Target |
COX-2:280 μM (IC50) COX-2:160 μM (IC50, in human blood) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 316.0±42.0 °C at 760 mmHg |
| Melting Point | 115 °C |
| Molecular Formula | C10H7F3O4 |
| Molecular Weight | 248.155 |
| Flash Point | 144.9±27.9 °C |
| Exact Mass | 248.029648 |
| PSA | 63.60000 |
| LogP | 2.90 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.484 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H317-H319-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-36/37/38-43 |
| Safety Phrases | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| RTECS | GP4250000 |
| HS Code | 2918990090 |
|
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322-79-2 |
| Literature: Journal of the American Chemical Society, , vol. 76, p. 1051,1054 |
|
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322-79-2 |
| Literature: Journal of the American Chemical Society, , vol. 76, p. 1051,1054 |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |