Name | 1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxy-5-phenyl-3-thienyl)methyl]-3,4-dihydro-5-methyl-2,4-dioxo-, (αS) |
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Synonyms |
Arecaidine propargyl ester tosylate
UPB 316 |
Description | UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a Kb value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist[1]. |
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Related Catalog | |
Target |
Kb: 1.4 nM (GluK1)[1] |
In Vitro | UBP316 is ineffective at GluK2 (GluR6) receptors at all concentrations tested (up to 100 μM) and had no effect at GluK3 (GluR7) when tested at 1 μM[1]. UBP316 (200 nM) reduces short-term facilitation of pre-synaptic calcium transients following repetitive spikes[1]. UBP316 effectively antagonises GluK1-mediated depression of excitatory transmission in CA1 region of the hippocampus in vitro[1]. UBP316 blocks induction of NMDA receptor-independent long-term potentiation (LTP)[1]. |
References |
Density | 1.474±0.06 g/cm3 (20 °C, 760 mmHg) |
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Boiling Point | 681.3±65.0 °C (760 mmHg) |
Melting Point | 275-278 °C (decomp) (water) |
Molecular Formula | C20H19N3O6S |
Molecular Weight | 429.44600 |
Exact Mass | 429.09900 |
PSA | 172.86000 |
LogP | 1.90560 |