CB2R/FAAH modulator-1

Names

[ CAS No. ]:
928892-60-8

[ Name ]:
CB2R/FAAH modulator-1

Biological Activity

[Description]:

CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH
Signaling Pathways >> Neuronal Signaling >> FAAH
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

CB2R:14.8 nM (Ki)

CB2R:123.6 nM (EC50)

CB1R:241.3 nM (Ki)

CB1R:489 nM (EC50)


[In Vitro]

CB2R/FAAH modulator-1 (化合物 13; 10 μM; 24 小时) 减少未刺激的单核细胞和巨噬细胞中促炎细胞因子 TNFα、IFN-γ、IL-1β 和 IL6 的产生[1] .

[References]

[1]. Francesca Intranuov, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H27NO2

[ Molecular Weight ]:
361.48

Related Compounds