Hepcidin-20 (human) trifluoroacetate salt

Names

[ CAS No. ]:
342790-23-2

[ Name ]:
Hepcidin-20 (human) trifluoroacetate salt

Biological Activity

[Description]:

Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Maisetta G, et al. pH-dependent disruption of Escherichia coli ATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25. FEBS J. 2013 Jun;280(12):2842-54.  

[2]. Del Gaudio G, et al. Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid. Antimicrob Agents Chemother. 2013 Sep;57(9):4314-4321.  

[3]. Brancatisano FL, et al. Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains of Staphylococcus epidermidis. Biofouling. 2014;30(4):435-46.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C85H135N27O23S9

[ Molecular Weight ]:
2191.73

[ Exact Mass ]:
2189.770996

[ LogP ]:
-3.90

[ Index of Refraction ]:
1.728

Related Compounds