Urotensin II (human) trifluoroacetate salt

Names

[ Name ]:
Urotensin II (human) trifluoroacetate salt

[Synonym ]:
m.w. 1388.57 c64h85n13o18s2
glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val hydrochloride
glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val
urotensin-ii
h-glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val-oh
GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL(DISULFIDE BRIDGE:CYS5-CYS10)
Urotensin II (114-124), human

Biological Activity

[Description]:

Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Cardiovascular Disease

[Target]

GPR14[1]

[In Vitro]

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].

[In Vivo]

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].

[References]

[1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₄H₈₅N₁₃O₁₈S₂

[ Molecular Weight ]:
1388.57

[ PSA ]:
580.00000

[ LogP ]:
2.88900

Related Compounds

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