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Neuropeptide S (human) trifluoroacetate salt

Names

[ CAS No. ]:
412938-67-1

[ Name ]:
Neuropeptide S (human) trifluoroacetate salt

[Synonym ]:
SFRNGVGTGMKKTSFQRAKS
H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH
Neuropeptide S,NPS,human
SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER
REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH

Biological Activity

[Description]:

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

EC50: 9.4 nM (neuropeptide S receptor)[1]


[In Vitro]

Neuropeptide S (human)(4 pM to 1.7 nM; 48 hours)retains full agonist activity with an EC50 of 6.7 ± 2.4 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 ± 0.12 nM)[1]. Neuropeptide S (human)(1 pM - 3 μM; 48 hours) are used to compete with 0.15 nM [125I] Y10-NPS, [125I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 ± 0.12 nM) [1].

[In Vivo]

Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nMor 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.

Chemical & Physical Properties

[ Molecular Formula ]:
C93H155N31O28S

[ Molecular Weight ]:
2187.48000

[ Exact Mass ]:
2186.14000

[ PSA ]:
1030.71000

Related Compounds