LRRK2-IN-4

Names

[ Name ]:
LRRK2-IN-4

Biological Activity

[Description]:

LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> LRRK2

Research Areas >> Neurological Disease

[Target]

IC50: 2.6 nM (LRRK2)[1]

[In Vivo]

LRRK2-IN-4 (compound 24) (p.o.) shows good oral bioavailability in male Wistar-Han rats (F=64%), male beagle dogs (F=65%)[1].

[References]

[1]. Keylor MH, et al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022; 65(1):838-856.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₉ClF₂N₆O₂

[ Molecular Weight ]:
518.99

Related Compounds

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