IRE1α kinase-IN-3

Names

[ CAS No. ]:
2416223-41-9

[ Name ]:
IRE1α kinase-IN-3

Biological Activity

[Description]:

IRE1α kinase-IN-3 (compound 2) is a potent IRE1α inhibitor with an Ki of 480 nM. IRE1α kinase-IN-3 is the ATP-competitive ligands of IRE1α[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Cell Cycle/DNA Damage >> IRE1

[Target]

Ki: 480 nM (IRE1α)[1]


[References]

[1]. Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17(11):1148-1156.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H32N6O3S

[ Molecular Weight ]:
544.67

Related Compounds