Multi-kinase-IN-3

Names

[ CAS No. ]:
2091950-43-3

[ Name ]:
Multi-kinase-IN-3

Biological Activity

[Description]:

Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

PDGFRβ:55 ± 2.6 nM (IC50)

VEGFR-2:58.3 ± 5.9 nM (IC50)


[References]

[1]. Qin M, et al. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115486.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H33N5O3

[ Molecular Weight ]:
547.65

Related Compounds