Rho-Kinase-IN-1

Names

[ CAS No. ]:
1035094-83-7

[ Name ]:
Rho-Kinase-IN-1

[Synonym ]:
1H-Indazol-5-amine, N-[1-[[4-(methylthio)phenyl]methyl]-3-piperidinyl]-
N-{1-[4-(Methylsulfanyl)benzyl]-3-piperidinyl}-1H-indazol-5-amine

Biological Activity

[Description]:

Rho-Kinase-IN-1 is a rho kinase inhibitor extracted from US 20090325960 A1, compound 1.008.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras
Research Areas >> Cancer

[Target]

Rho kinase[1]


[In Vitro]

Rho-Kinase-IN-1 is a rho kinaseinhibitor which can be useful for treating diseases or conditions associated with excessive cell proliferation, remodeling, edema and inflammation[1].

[References]

[1]. Fulcher, Emilee H, et al. Method for the treatment and prevention of the inflammatory diseases using Rho kinase inhibiting compounds. US 20090325960 A1.


[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | CASIN | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | K-Ras(G12C) inhibitor 12 | ZCL 278 | Y16

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
567.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H24N4S

[ Molecular Weight ]:
352.496

[ Flash Point ]:
296.7±30.1 °C

[ Exact Mass ]:
352.172180

[ LogP ]:
3.56

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.687

[ Storage condition ]:
2-8℃

Related Compounds