K-Ras(G12C) inhibitor 12

Names

[ Name ]:
K-Ras(G12C) inhibitor 12

[Synonym ]:
1-(4-(2-((4-Chloro-2-hydroxy-5-iodophenyl)amino)acetyl)piperazin-1-yl)prop-2-en-1-one
2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-
1-(4-{[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl}-1-piperazinyl)-2-propen-1-one
K-Ras(G12C) inhibitor 12
1-[4-[2-[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-2-propen-1-one

Biological Activity

[Description]:

K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.IC50 value: 0.32 μM (EC50)Target: K-RasBinding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K-Ras(G12C) inhibitor 12, K-Ras(G12C) shows a slight preference for GTP (relative affinity 0.6).

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras

Research Areas >> Cancer

[References]

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-551.

[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | CASIN | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | ZCL 278 | Y16 | BQU57

Chemical & Physical Properties

[ Density]:
1.736±0.06 g/cm3

[ Boiling Point ]:
680.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₇ClIN₃O₃

[ Molecular Weight ]:
449.671

[ Flash Point ]:
365.2±31.5 °C

[ Exact Mass ]:
449.000305

[ PSA ]:
72.88000

[ LogP ]:
2.84

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.674

[ Water Solubility ]:
Practically insoluble (0.01 g/L) (25 ºC)

Safety Information

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%