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K-Ras G12C-IN-3

Names

[ CAS No. ]:
1629268-19-4

[ Name ]:
K-Ras G12C-IN-3

[Synonym ]:
2-Propen-1-one, 1-[4-[(2',5',6-trichloro-4-methoxy[1,1'-biphenyl]-3-yl)carbonyl]-1-piperazinyl]-
1-{4-[(2',5',6-Trichloro-4-methoxy-3-biphenylyl)carbonyl]-1-piperazinyl}-2-propen-1-one

Biological Activity

[Description]:

K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.IC50 value:Target: K-ras G12C inhibitorFor more information, please see the following patent.Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereofBy Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras
Research Areas >> Cancer

[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | CASIN | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | K-Ras(G12C) inhibitor 12 | ZCL 278 | Y16

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
655.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H19Cl3N2O3

[ Molecular Weight ]:
453.746

[ Flash Point ]:
349.9±31.5 °C

[ Exact Mass ]:
452.046112

[ LogP ]:
3.39

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.604

[ Storage condition ]:
2-8℃

Related Compounds