CASIN

Names

[ Name ]:
CASIN

[Synonym ]:
Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-
2-[(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol

Biological Activity

[Description]:

CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. In vitro: Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells In vivo: Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras

Research Areas >> Cancer

[References]

[1]. Florian MC et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell, 2012 May 4, 10(5):520-30.

[2]. Peterson JR et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.

[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | K-Ras(G12C) inhibitor 12 | ZCL 278 | Y16 | BQU57

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
577.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂N₂O

[ Molecular Weight ]:
306.401

[ Flash Point ]:
303.3±30.1 °C

[ Exact Mass ]:
306.173218

[ LogP ]:
3.60

[ Appearance of Characters ]:
light yellow solid

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.682

[ Storage condition ]:
-20℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport