425399-05-9
425399-05-9 structure
- Name: CASIN
- Chemical Name: CASIN
- CAS Number: 425399-05-9
- Molecular Formula: C20H22N2O
- Molecular Weight: 306.401
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2018-01-16 19:50:47
- Modify Date: 2025-08-25 19:32:28
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CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. In vitro: Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells In vivo: Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs.
| Name | CASIN |
|---|---|
| Synonyms |
Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-
2-[(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol |
| Description | CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. In vitro: Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells In vivo: Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 577.8±50.0 °C at 760 mmHg |
| Molecular Formula | C20H22N2O |
| Molecular Weight | 306.401 |
| Flash Point | 303.3±30.1 °C |
| Exact Mass | 306.173218 |
| LogP | 3.60 |
| Appearance | light yellow solid |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.682 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
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