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  • DC Chemicals Limited
  • China
  • Product Name: CASIN
  • Price: $500.0/100mg $850.0/250mg $1700.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

425399-05-9

425399-05-9 structure
425399-05-9 structure
  • Name: CASIN
  • Chemical Name: CASIN
  • CAS Number: 425399-05-9
  • Molecular Formula: C20H22N2O
  • Molecular Weight: 306.401
  • Catalog: Signaling Pathways GPCR/G Protein Ras
  • Create Date: 2018-01-16 19:50:47
  • Modify Date: 2024-01-02 16:26:20
  • CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. In vitro: Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells In vivo: Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs.

Name CASIN
Synonyms Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-
2-[(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol
Description CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. In vitro: Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells In vivo: Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs.
Related Catalog
References

[1]. Florian MC et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell, 2012 May 4, 10(5):520-30.

[2]. Peterson JR et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.

Density 1.2±0.1 g/cm3
Boiling Point 577.8±50.0 °C at 760 mmHg
Molecular Formula C20H22N2O
Molecular Weight 306.401
Flash Point 303.3±30.1 °C
Exact Mass 306.173218
LogP 3.60
Appearance light yellow solid
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.682
Storage condition -20℃
RIDADR NONH for all modes of transport