γ-Secretase modulator 12

Names

[ CAS No. ]:
2204249-82-9

[ Name ]:
γ-Secretase modulator 12

Biological Activity

[Description]:

γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Ryuichi Sekioka, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators. Bioorg Med Chem. 2020 Jan 1;28(1):115132.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H23N3O2

[ Molecular Weight ]:
397.47

Related Compounds