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γ-secretase modulator 14a

Names

[ CAS No. ]:
1485066-18-9

[ Name ]:
γ-secretase modulator 14a

[Synonym ]:
N-(4-Fluorophenyl)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-1,2-benzoxazol-7-amine
1,2-Benzisoxazol-7-amine, N-(4-fluorophenyl)-4,5,6,7-tetrahydro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-

Biological Activity

[Description]:

A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM; shows good to excellent selectivity for the reduction of Aβ42 in the cellular assays; significantly reduces Aβ42 in the CNS compartment in vivo in nontransgenic rat models.

[References]

References 1. Zhao Z, et al. ACS Med Chem Lett. 2017 Sep 19;8(10):1002-1006. View Related Products by Target γ-secretase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
648.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H23FN4O2

[ Molecular Weight ]:
418.463

[ Flash Point ]:
345.7±31.5 °C

[ Exact Mass ]:
418.180511

[ LogP ]:
4.21

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.656

Related Compounds