2204249-82-9

2204249-82-9 structure

Name: γ-Secretase modulator 12
Chemical Name: γ-Secretase modulator 12
CAS Number: 2204249-82-9
Molecular Formula: C₂₅H₂₃N₃O₂
Molecular Weight: 397.47
Catalog: Research Areas Neurological Disease
Create Date: 2022-08-12 17:40:42
Modify Date: 2025-08-25 19:18:21
γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].

Name	γ-Secretase modulator 12

Description	γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Ryuichi Sekioka, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators. Bioorg Med Chem. 2020 Jan 1;28(1):115132.

Molecular Formula	C₂₅H₂₃N₃O₂
Molecular Weight	397.47