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Benzalkonium chloride

Names

[ CAS No. ]:
8001-54-5

[ Name ]:
Benzalkonium chloride

[Synonym ]:
Benzenemethanaminium, N,N-dimethyl-N-tridecyl-, chloride (1:1)
MFCD00050250
N-Benzyl-N,N-dimethyltridecan-1-aminium chloride
EINECS 264-151-6
N-Benzyl-N,N-dimethyl-1-tridecanaminium chloride
Alkyldimethylbenzylammonium Chloride
Benzalkonium Chloride

Biological Activity

[Description]:

Benzalkonium chloride is a potent anti-microbial agent, used as a preservative in eye drops.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection

[In Vitro]

Benzalkonium chloride (0.0001%-0.5%) results in a dose-dependent cytotoxicity in cells. Benzalkonium chloride also shows cytotoxicity against human keratinocytes, with 50% loss of viability of 4 μM. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED50 of 3.9 and 62 μM, respectively. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1].

[In Vivo]

Benzalkonium chloride (0.02%) causes no abnormalities in the nasal epithelium of the monkeys after light and electron microscopical examination. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1].

[References]

[1]. Johnson NF. Pulmonary Toxicity of Benzalkonium Chloride. J Aerosol Med Pulm Drug Deliv. 2017 Jul 6.


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Chemical & Physical Properties

[ Density]:
0.98

[ Boiling Point ]:
>100°C/760mmHg

[ Molecular Formula ]:
C6H5CH2N(CH3)2RCl(R=C8H17toC18H37)

[ Molecular Weight ]:
354.013

[ Exact Mass ]:
353.284943

[ LogP ]:
7.76610

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, moisture. Hygroscopic.

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
C;N

[ Risk Phrases ]:
R34;R50;R21/22

[ Safety Phrases ]:
S45;S61;S36/S37/S39

[ RIDADR ]:
UN 3261 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BO3151000

Related Compounds