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Sulbactam pivoxil

Names

[ CAS No. ]:
69388-79-0

[ Name ]:
Sulbactam pivoxil

[Synonym ]:
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2,2-dimethyl-1-oxopropoxy)methyl ester, (2S-cis)-
Hydroxymethyl (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Pivalate (Ester) 4,4-Dioxide
sulbactam pivaloyl-oxymethyl ester
(2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-Dioxide (2,2-Dimethyl-1-oxopropoxy)methyl Ester
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, 4,4-dioxide, (2S,5R)-
SULBACTAM PIVOXIL
Sulbactam pivoxyl
1,1-dioxopenicillanic acid pivaloyloxymethyl ester
[(2,2-Dimethylpropanoyl)oxy]methyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
Pivsulbactam
Pivoxil sulbactam

Biological Activity

[Description]:

Sulbactam pivoxil is a prodrug of sulbactam. Sulbactam is a β-lactamase inhibitor which poorly adsorbed from gastrointestinal tract. Sulbactam pivoxil has a better absorption than the parent drug and provides high serum levels after oral administration[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Changov LS, et al. An efficient method for the synthesis of sulbactam pivoxil. Farmaco. 2000;55(2):134-135.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
537.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H21NO7S

[ Molecular Weight ]:
347.384

[ Flash Point ]:
278.9±30.1 °C

[ Exact Mass ]:
347.103882

[ PSA ]:
115.43000

[ LogP ]:
-0.02

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.538

Safety Information

[ Hazard Codes ]:
Xn

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds