H-Glu(OEt)-OEt.HCl

Names

[ Name ]:
H-Glu(OEt)-OEt.HCl

[Synonym ]:
L-Glutamic acid, diethyl ester, hydrochloride (1:1)
Glutamic acid, diethyl ester, hydrochloride (1:1)
diethyl (2S)-2-aminopentanedioate,hydrochloride
MFCD00012509
Diethyl L-Glutamate Hydrochloride
Diethyl L-glutamate hydrochloride (1:1)
H-Glu(OEt)-OEt·HCl
Diethyl glutamate hydrochloride (1:1)
L-Glutamic Acid Diethyl Ester Hydrochloride
EINECS 214-270-4
H-Glu(OEt)-OEt.HCl

Biological Activity

[Description]:

H-Glu(OEt)-OEt.HCl is a glutamic acid derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.08g/cm3

[ Boiling Point ]:
262ºC at 760 mmHg

[ Melting Point ]:
108-110 °C(lit.)

[ Molecular Formula ]:
C₉H₁₈ClNO₄

[ Molecular Weight ]:
239.697

[ Flash Point ]:
86.3ºC

[ Exact Mass ]:
239.092438

[ PSA ]:
78.62000

[ LogP ]:
1.72240

[ Vapour Pressure ]:
0.0112mmHg at 25°C

[ Index of Refraction ]:
22.5 ° (C=3.6, EtOH)

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA1252280

CHEMICAL NAME :: L-Glutamic acid, diethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 1118-89-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H17-N-O4.Cl-H

MOLECULAR WEIGHT :: 239.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,246,1991

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MA1252280

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Fast-acting excitatory amino acids are involved in the enhancement of the aversiveness of the electrical stimulation of the inferior colliculus by systemic injections of muscimol.

Life Sci. 71(25) , 2961-72, (2002)

Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated...

Glycine increases arterial pressure and augments NMDA-induced pressor responses in the dorsomedial and ventrolateral medulla of cats.

J. Auton. Nerv. Syst. 67(3) , 145-55, (1997)

The present study is designed to determine and characterize two neurobiological events. Firstly, we investigated whether increases of systemic arterial pressure (SAP) and sympathetic vertebral nerve a...

Mass spectrometric and kinetic studies on slow progression of papain-catalyzed polymerization of L-glutamic acid diethyl ester.

Biochim. Biophys. Acta 1780(6) , 881-91, (2008)

Papain polymerizes L-glutamic acid diethyl ester (Glu-di-OEt) regioselectively, resulting in the formation of poly (gamma-ethyl alpha-L-glutamic acid) with various degrees of polymerization of less th...