2,4-Difluoronitrobenzene

Names

[ CAS No. ]:
446-35-5

[ Name ]:
2,4-Difluoronitrobenzene

[Synonym ]:
2,4-difluoro-1-nitro-benzene
2.4 DFNB
2,4-difluoro-1-nitro-benzen
2,4-DIFLUORO NITROBENZEN
MFCD00007050
1,3-difluoro-4-nitrobenzene
2,4-Difluronitrobenzene
3,5-diflurobenzonitrile
2,4-Difluoronitroben
1-nitro-2,4-difluorobenzene
Benzene, 2,4-difluoro-1-nitro-
2,4-Difluoro-1-nitrobenzene
EINECS 207-167-0
2,4-Difluoronitribenzene
2,4-Difluoronitrobenzene

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
207.0±0.0 °C at 760 mmHg

[ Melting Point ]:
9-10 °C(lit.)

[ Molecular Formula ]:
C₆H₃F₂NO₂

[ Molecular Weight ]:
159.090

[ Flash Point ]:
90.6±0.0 °C

[ Exact Mass ]:
159.013184

[ PSA ]:
45.82000

[ LogP ]:
1.58

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
0.3±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.510

[ Stability ]:
Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ5730000

CHEMICAL NAME :: Benzene, 2,4-difluoro-1-nitro-

CAS REGISTRY NUMBER :: 446-35-5

BEILSTEIN REFERENCE NO. :: 2048034

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H3-F2-N-O2

MOLECULAR WEIGHT :: 159.10

WISWESSER LINE NOTATION :: WNR BF DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1290 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 80 nL/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,217,1983

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R23/24/25;R36/37/38

[ Safety Phrases ]:
S26-S45-S36/37/39-S23

[ RIDADR ]:
UN 2810 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
CZ5730000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2904909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2904909090

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline. Selvakumar N, et al.

Tetrahedron Lett. 43(50) , 9175-78, (2002)

A solid phase traceless synthesis of 2-arylaminobenzimidazoles. Krchnák V, et al.

Tetrahedron Lett. 42(9) , 1627-30, (2001)

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.

Angew. Chem. Int. Ed. Engl. 51(28) , 7028-30, (2012)

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desi...