2,4-Difluoroaniline

Names

[ CAS No. ]:
367-25-9

[ Name ]:
2,4-Difluoroaniline

[Synonym ]:
2,4-difluorophenylamine
2,4-DIFLOUROANILINE
Benzenamine, 2,4-difluoro-
Difluoroaniline
4-Difluoroaniline
2,4-Difluoranilin
2,4-difluoro-anilin
2,4-difluorobenzenamine
2,4-difluorobenzeneamine
Aniline,2,4-difluoro
EINECS 206-687-5
2,4-Difluoroaniline
4-fluoro-2-fluoroaniline
MFCD00007648
2,4-Difluoro-aniline
2,4-DIFLUROANILINE
2,4,6-TRIFLUOROPHENYL ISOCYANATE
2,4-fluoroaniline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
168.4±20.0 °C at 760 mmHg

[ Melting Point ]:
−7.5 °C(lit.)

[ Molecular Formula ]:
C₆H₅F₂N

[ Molecular Weight ]:
129.107

[ Flash Point ]:
62.8±0.0 °C

[ Exact Mass ]:
129.039001

[ PSA ]:
26.02000

[ LogP ]:
1.52

[ Vapour Pressure ]:
1.6±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.521

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.

[ Water Solubility ]:
1-5 g/100 mL at 20.55 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX3680000

CHEMICAL NAME :: Aniline, 2,4-difluoro-

CAS REGISTRY NUMBER :: 367-25-9

BEILSTEIN REFERENCE NO. :: 2802556

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H5-F2-N

MOLECULAR WEIGHT :: 129.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H311-H331

[ Precautionary Statements ]:
P261-P280-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S28-S36/37/39-S26

[ RIDADR ]:
UN 2941 6.1/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
BX3680000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses.

Int. Arch. Occup. Environ. Health 54(3) , 223-32, (1984)

Two possible methods for monitoring exposure to 2,4-difluoroaniline and 4-fluoroaniline have been investigated: measurement of methaemoglobin content in blood and measurement of urinary metabolites. E...

Subacute toxicity assessment of water disinfection byproducts on zebrafish.

Pathol. Oncol. Res. 18(3) , 579-84, (2012)

Disinfection of raw water is essential to the production of drinking water. However, by-products of disinfection may exert toxic effects. The potential toxic effects of two of these compounds, 4-ethyl...

High resolution NMR study of T1 magnetic relaxation dispersion. III. Influence of spin 1/2 hetero-nuclei on spin relaxation and polarization transfer among strongly coupled protons.

J. Chem. Phys. 137(9) , 094503, (2012)

Effects of spin-spin interactions on the nuclear magnetic relaxation dispersion (NMRD) of protons were studied in a situation where spin ½ hetero-nuclei are present in the molecule. As in earlier work...