1,3,5-Trichlorobenzene
Names
[ CAS No. ]:
108-70-3
[ Name ]:
1,3,5-Trichlorobenzene
[Synonym ]:
1,3,5-TRICHLORO-BENZENE
s-Trichlorobenzene
1,3,5,-Trichlorobenzene
Benzene, 1,3,5-trichloro-
sym-Trichlorobenzene
1,3,5-Trichlorobenzene
3,5-dichlorophenyl chloride
MFCD00000585
Benzene,1,3,5-trichloro
EINECS 203-608-6
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
211.3±20.0 °C at 760 mmHg
[ Melting Point ]:
63 °C
[ Molecular Formula ]:
C6H3Cl3
[ Molecular Weight ]:
181.447
[ Flash Point ]:
126.7±0.0 °C
[ Exact Mass ]:
179.930038
[ LogP ]:
4.04
[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.567
[ Stability ]:
Stable. Incompatible with acids, strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DC2100100
- CHEMICAL NAME :
- Benzene, 1,3,5-trichloro-
- CAS REGISTRY NUMBER :
- 108-70-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C6-H3-Cl3
- MOLECULAR WEIGHT :
- 181.44
- WISWESSER LINE NOTATION :
- GR CG EG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2260 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7380 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 425 mg/kg/24H
- REFERENCE :
- MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,111,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2497 No. of Facilities: 60 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 1673 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H412
[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R38
[ Safety Phrases ]:
S26-S36-S36/37-S61
[ RIDADR ]:
3077
[ WGK Germany ]:
3
[ RTECS ]:
DC2100100
[ Packaging Group ]:
III
[ Hazard Class ]:
9
[ HS Code ]:
2903999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903999090
[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Eur. J. Med. Chem. 43 , 714-40, (2008)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...
Evaluation of injection methods for fast, high peak capacity separations with low thermal mass gas chromatography.J. Chromatogr. A. 1392 , 82-90, (2015)
Low thermal mass gas chromatography (LTM-GC) was evaluated for rapid, high peak capacity separations with three injection methods: liquid, headspace solid phase micro-extraction (HS-SPME), and direct ...
Determination of chlorobenzenes in water samples by solid-phase disk extraction and gas chromatography-electron capture detection.J. Chromatogr. Sci. 52(5) , 375-82, (2014)
A simple, rapid, sensitive and high throughput method is described, based on solid-phase disk extraction (SPDE) and gas chromatography-electron capture detection, for the determination of chlorobenzen...