Phenolphthalein
Names
[ CAS No. ]:
77-09-8
[ Name ]:
Phenolphthalein
[Synonym ]:
Evac-U-Gen
a-(p-Hydroxyphenyl)-a-(4-oxo-2,5-cyclohexadien-1-ylidine)-o-toluic Acid
Phenolphthalein
White phenolphthalein
Evac-Q-Kit
Ex-Lax
Evac-Q-Tabs
MFCD00005913
Chocolax
EINECS 201-004-7
Evac-Q-Kwik
3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofurunone
1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
5-18-04-00188 (Beilstein Handbook Reference)
Colax
Purgophen (VAN)
Feen-A-Mint Laxative Mints
3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one
Evac-V-Lax
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
557.8±50.0 °C at 760 mmHg
[ Melting Point ]:
258-263 °C
[ Molecular Formula ]:
C20H14O4
[ Molecular Weight ]:
318.323
[ Flash Point ]:
206.5±23.6 °C
[ Exact Mass ]:
318.089203
[ PSA ]:
66.76000
[ LogP ]:
2.63
[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C
[ Index of Refraction ]:
1.693
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, alkalies.
[ Water Solubility ]:
<0.1 g/100 mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SM8380000
- CHEMICAL NAME :
- Phenolphthalein
- CAS REGISTRY NUMBER :
- 77-09-8
- BEILSTEIN REFERENCE NO. :
- 0284423
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C20-H14-O4
- MOLECULAR WEIGHT :
- 318.34
- WISWESSER LINE NOTATION :
- T56 BVO DHJ D- D-/R DQ 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 29 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - gastritis Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - other changes in urine composition
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 324 gm/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 106 gm/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 364 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - adrenal cortex tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 281 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 50 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,151,1995 *** REVIEWS *** TOXICOLOGY REVIEW DAPOAG Deutsche Apotheker. (Postfach 1650, 6370 Oberusel/Taunas, Fed. Rep. Ger.) V.1- 1949- Volume(issue)/page/year: 27,151,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0011 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 31 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 56240 No. of Facilities: 6160 (estimated) No. of Industries: 102 No. of Occupations: 43 No. of Employees: 43092 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9187 No. of Facilities: 117 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1946 (estimated) No. of Female Employees: 1408 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 56240 No. of Facilities: 6900 (estimated) No. of Industries: 89 No. of Occupations: 57 No. of Employees: 73297 (estimated) No. of Female Employees: 18309 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H319-H341-H350
[ Precautionary Statements ]:
P201-P210-P280-P308 + P313-P337 + P313-P403 + P235
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R40
[ Safety Phrases ]:
S45-S36/37-S33-S24-S16-S7
[ RIDADR ]:
UN 1993
[ RTECS ]:
SM8380000
[ Hazard Class ]:
3.0
[ HS Code ]:
29322910
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29322910
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