1-HYDROXYANTHRAQUINONE

Names

[ CAS No. ]:
129-43-1

[ Name ]:
1-HYDROXYANTHRAQUINONE

[Synonym ]:
9,10-Anthracenedione, 1-hydroxy-
EINECS 204-946-7
1-HYDROXYANTHRAQUINONE
1-hydroxyanthracene-9,10-dione
1-Hydroxy-9,10-anthraquinone
HYDROXY-9,10-ANTHRACENEDIONE
MFCD00058946
1-Hydroxy anthraquinone

Biological Activity

[Description]:

1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vivo]

1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1]. Animal Model: Thirty rats[1]. Dosage: 1% HA in diet. Administration: Diet. Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment. One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becomingmoribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of totalintake of HA/rat was 76.8 g).

[References]

[1]. H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
414.8±14.0 °C at 760 mmHg

[ Melting Point ]:
194°C

[ Molecular Formula ]:
C₁₄H₈O₃

[ Molecular Weight ]:
224.212

[ Flash Point ]:
218.8±16.6 °C

[ Exact Mass ]:
224.047348

[ PSA ]:
54.37000

[ LogP ]:
3.97

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.695

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB7178000

CHEMICAL NAME :: Anthraquinone, 1-hydroxy-

CAS REGISTRY NUMBER :: 129-43-1

BEILSTEIN REFERENCE NO. :: 1912751

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H8-O3

MOLECULAR WEIGHT :: 224.22

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 288 gm/kg/68W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 147 gm/kg/42W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 50 umol/L

REFERENCE :: CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,457,1986

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36/37/39

[ RTECS ]:
CB7178000

[ Packaging Group ]:
III

[ HS Code ]:
2914690090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Related Compounds

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