ERα antagonist 1

Names

[ CAS No. ]:
2762423-09-4

[ Name ]:
ERα antagonist 1

Biological Activity

[Description]:

ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[Target]

ERα


[References]

[1]. Bai C, et al. Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities. Bioorg Med Chem. 2021 Oct 1;47:116395.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H32N2O5S

[ Molecular Weight ]:
568.68

Related Compounds