ERRα antagonist-1

Names

[ Name ]:
ERRα antagonist-1

[Synonym ]:
N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine

Biological Activity

[Description]:

ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cancer

[Target]

ERRα

[References]

[1]. Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉N₃S₂

[ Molecular Weight ]:
377.52600

[ Exact Mass ]:
377.10200

[ PSA ]:
78.56000

[ LogP ]:
4.14090

Related Compounds

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