CCR8 antagonist 2

CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the treatment of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220)[1].

Signaling Pathways >> GPCR/G Protein >> CCR

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> CCR

Research Areas >> Neurological Disease

[1]. Guohuang FAN, et al. Methods and compositions for targeting tregs using ccr8 inhibitors.