Mcl1-IN-11

Names

[ CAS No. ]:
2042211-13-0

[ Name ]:
Mcl1-IN-11

Biological Activity

[Description]:

Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Ki: 0.06 (Mcl-1), 4.2 μM (Bcl-2)[1]


[References]

[1]. Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211.

Chemical & Physical Properties

[ Molecular Formula ]:
C38H41N3O5S2

[ Molecular Weight ]:
683.88

Related Compounds