Mcl1-IN-9

Names

[ Name ]:
Mcl1-IN-9

[Description]:

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Mcl-1:0.03 nM (Ki)

[In Vitro]

Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].

[In Vivo]

Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].

[References]

[ Molecular Formula ]:
C₃₇H₃₉ClN₄O₄

[ Molecular Weight ]:
639.18