PF-06471553
Names
[ CAS No. ]:
1808094-07-6
[ Name ]:
PF-06471553
Biological Activity
[Description]:
PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.
[Related Catalog]:
[Target]
IC50: 92 nM (MGAT3)[1]
[In Vitro]
PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC50, >50 μM), DGAT2 (IC50, >100 μM), MGAT1 (IC50, 14.9 μM), and MGAT2 (IC50, 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC50 of 205 nM (pIC50, 6.69)[1].
[In Vivo]
PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice[1].
[References]
[Related Small Molecules]
Avasimibe
|
LCQ-908
|
DGAT-3
|
A922500
|
Xanthohumol
|
PF-04620110
|
AZD7687
|
MGAT2-IN-1
|
DGAT-1 inhibitor 2
|
DGAT1-IN-1
|
K-604 dihydrochloride
|
YM17E
|
ABT-046
|
RP 70676
|
Furan-2-carboxylic acid
Chemical & Physical Properties
[ Molecular Formula ]:
C23H25N5O4S
[ Molecular Weight ]:
467.54
[ Storage condition ]:
2-8℃