DGAT1-IN-1

Names

[ Name ]:
DGAT1-IN-1

[Synonym ]:
{trans-4-[4-(2-{[4-(Trifluoromethoxy)benzyl]carbamoyl}imidazo[1,2-a]pyridin-6-yl)phenyl]cyclohexyl}acetic acid
Cyclohexaneacetic acid, 4-[4-[2-[[[[4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]imidazo[1,2-a]pyridin-6-yl]phenyl]-, trans-
DGAT1-IN-1

Biological Activity

[Description]:

DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).IC50 value: < 10 nMTarget: DGAT1 inhibitorImidazopyridine and imidazothiazole compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme and their preparationBy Kim, Dooseop; Bok, Juhan; Shin, Sunmi From PCT Int. Appl. (2013), WO 2013119040 A1 20130815.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase

Research Areas >> Metabolic Disease

[References]

[1]. Compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme , Patent: WO 2013119040 A1

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₃₀H₂₈F₃N₃O₄

[ Molecular Weight ]:
551.556

[ Exact Mass ]:
551.203186

[ LogP ]:
6.92

[ Index of Refraction ]:
1.620

[ Storage condition ]:
2-8℃

Related Compounds

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