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LCQ-908

Names

[ CAS No. ]:
956136-95-1

[ Name ]:
LCQ-908

[Synonym ]:
Pradigastat [INN]
{trans-4-[4-(5-{[6-(Trifluoromethyl)-3-pyridinyl]amino}-2-pyridinyl)phenyl]cyclohexyl}acetic acid
Cyclohexaneacetic acid, 4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]-, trans-
LCQ 908
Pradigastat
LCQ 908NXA
UNII-2U23G6VNUZ
LCQ908-NXA
LCQ-908

Biological Activity

[Description]:

Pradigastat (LCQ-908) is a diacylglycerol acyltransferase 1 (DGAT1) inhibitor.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase
Research Areas >> Metabolic Disease

[In Vivo]

Pradigastat (LCQ-908) is a potent inhibitor of DGAT1, and has been used for the phase II clinical trials to treat diabetes and obesity[1].

[References]

[1]. Birch AM, et al. DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96.


[Related Small Molecules]

Avasimibe | DGAT-3 | A922500 | Xanthohumol | PF-04620110 | AZD7687 | MGAT2-IN-1 | DGAT-1 inhibitor 2 | DGAT1-IN-1 | K-604 dihydrochloride | PF-06471553 | YM17E | ABT-046 | RP 70676 | Furan-2-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
611.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H24F3N3O2

[ Molecular Weight ]:
455.472

[ Flash Point ]:
323.3±31.5 °C

[ Exact Mass ]:
455.182068

[ PSA ]:
75.11000

[ LogP ]:
6.10

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
2-8℃

Related Compounds