RO 19-4603

Names

[ Name ]:
RO 19-4603

[Synonym ]:
Tocris-1995

Biological Activity

[Description]:

Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vivo]

Ro19-4603 (0-0.3 mg/kg，腹腔注射) 显着降低嗜酒大鼠在 8 小时间隔内的乙醇摄入量[1]。 Animal Model: Alcohol-Preferring rats[1] Dosage: 0.075, 0.150, and 0.30 mg/kg. Administration: i.p. Result: Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval.

[References]

[1]. June HL, et al. The benzodiazepine inverse agonist RO19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats. Psychopharmacology (Berl). 1994 Jul;115(3):325-31.

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Boiling Point ]:
537.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₇N₃O₃S

[ Molecular Weight ]:
319.38

[ Flash Point ]:
279ºC

[ Exact Mass ]:
319.09900

[ PSA ]:
92.67000

[ LogP ]:
2.41260

[ Index of Refraction ]:
1.659

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.