99632-94-7

99632-94-7 structure

Name: RO 19-4603
Chemical Name: tert.-butyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate
CAS Number: 99632-94-7
Molecular Formula: C₁₅H₁₇N₃O₃S
Molecular Weight: 319.38
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-12-31 13:14:17
Modify Date: 2024-03-03 19:10:57
Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats[1].

Name	tert.-butyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate
Synonyms	Tocris-1995

Description	Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo	Ro19-4603 (0-0.3 mg/kg，腹腔注射) 显着降低嗜酒大鼠在 8 小时间隔内的乙醇摄入量[1]。 Animal Model: Alcohol-Preferring rats[1] Dosage: 0.075, 0.150, and 0.30 mg/kg. Administration: i.p. Result: Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval.
References	[1]. June HL, et al. The benzodiazepine inverse agonist RO19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats. Psychopharmacology (Berl). 1994 Jul;115(3):325-31.