1,1'-Diethyl-2,2'-cyanine iodide

Names

[ CAS No. ]:
977-96-8

[ Name ]:
1,1'-Diethyl-2,2'-cyanine iodide

[Synonym ]:
1,1'-DIETHYL-2,2'-CYANINE IODIDE
EINECS 213-556-6
MFCD00011971

Biological Activity

[Description]:

Pseudoisocyanine (iodide) is a pan inhibitor of monoamine transporters and organic cation transporters with antidepressant-like activity[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter

[References]

[1]. Fraser-Spears R, et al. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. Eur J Pharmacol. 2019 Jan 5;842:351-364.

Chemical & Physical Properties

[ Melting Point ]:
273ºC

[ Molecular Formula ]:
C₂₃H₂₃IN₂

[ Molecular Weight ]:
454.34700

[ Exact Mass ]:
454.09100

[ PSA ]:
8.81000

[ LogP ]:
1.23570

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H330-H312-H315-H319-H335

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
45

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression.

J. Neurosci. 33(25) , 10534-43, (2013)

Mood disorders cause much suffering and lost productivity worldwide, compounded by the fact that many patients are not effectively treated by currently available medications. The most commonly prescri...

Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells.

Inflamm. Res. 58 Suppl 1 , 61-2, (2009)

Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus.

Brain Res. 1063(1) , 69-76, (2005)

In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not ...