TC-T 6000

Names

[ CAS No. ]:
949467-71-4

[ Name ]:
TC-T 6000

[Synonym ]:
2,2'-({4,8-bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl}diimino)diethanol
Ethanol, 2,2'-[[4,8-bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino]bis-
2,2'-{[4,8-Bis(diisobutylamino)pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino}diethanol
2,2'-[[4,8-Bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino]bis-ethanol

Biological Activity

[Description]:

hENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter

[References]

[1]. Wang C, et al. Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem Pharmacol. 2013 Dec 1;86(11):1531-40.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
660.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H48N8O2

[ Molecular Weight ]:
504.71

[ Flash Point ]:
352.9±34.3 °C

[ Exact Mass ]:
504.390015

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.609

Related Compounds