dynorphin (1-11), Pro(10)-
Names
[ CAS No. ]:
94596-26-6
[ Name ]:
dynorphin (1-11), Pro(10)-
[Synonym ]:
DYNORPHIN (1-11),PRO(10)-
YGGFLRRIRDPK
α-Neoendorphin (pig), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline-
Biological Activity
[Description]:
[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2].
[Related Catalog]:
[In Vitro]
[DPro10] Dynorphin A (1-11), porcine has inhibition of adenylyl cyclase activity in k-opioid receptor-expressing CHO cells with an IC50 value of 0.12 nM[1].
[In Vivo]
[DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially[2].
Chemical & Physical Properties
[ Density]:
1.42±0.1 g/cm3 (20 °C, 760 mmHg)
[ Molecular Formula ]:
C63H103N21O13
[ Molecular Weight ]:
1362.62000
[ Exact Mass ]:
1361.80000
[ PSA ]:
577.48000
[ LogP ]:
4.64670