SMER18

Names

[ Name ]:
SMER18

[Synonym ]:
(2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]-2-buten-1-one
(2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]but-2-en-1-one
2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-

Biological Activity

[Description]:

SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Cancer

[References]

[1]. Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
458.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄ClNO₂

[ Molecular Weight ]:
287.741

[ Flash Point ]:
231.2±28.7 °C

[ Exact Mass ]:
287.071320

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.656

[ Storage condition ]:
2-8℃

Related Compounds

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