944153-47-3

944153-47-3 structure

Name: SMER18
Chemical Name: SMER18
CAS Number: 944153-47-3
Molecular Formula: C₁₆H₁₄ClNO₂
Molecular Weight: 287.741
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-04-28 04:00:53
Modify Date: 2024-01-08 18:26:20
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential.

Name	SMER18
Synonyms	(2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]-2-buten-1-one (2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]but-2-en-1-one 2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-

Description	SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer
References	[1]. Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338.