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DPNI-caged-GABA

Names

[ CAS No. ]:
927866-58-8

[ Name ]:
DPNI-caged-GABA

[Synonym ]:
DPNI-CAGED GABA
DPNI-caged-GABA
4-Amino-1-[2,3-dihydro-7-nitro-4-[2-(phosphonooxy)-1-[(phosphonooxy)methyl]ethoxy]-1H-indol-1-yl]-1-butanone
Bicifadine hydrochloride

Biological Activity

[Description]:

DPNI-GABA is a nitroindoline cage compound that inhibits GABA(A) receptors and reduces GABA-evoked peak responses with an IC50 value of 0.5 mM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Trigo FF, et al. Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ. J Neurosci Methods. 2009 Jul 30;181(2):159-69.  

Chemical & Physical Properties

[ Density]:
1.676±0.06 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
900.8±75.0 °C (760 mmHg)

[ Molecular Formula ]:
C15H23N3O12P2

[ Molecular Weight ]:
499.30

[ Exact Mass ]:
499.07600

[ PSA ]:
254.52000

[ LogP ]:
1.47730

Related Compounds