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NPEC-caged-(S)-AMPA

Names

[ CAS No. ]:
1257323-84-4

[ Name ]:
NPEC-caged-(S)-AMPA

[Synonym ]:
3-(5-Methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)-N-{[1-(2-nitrophenyl)ethoxy]carbonyl}-L-alanine
4-Isoxazolepropanoic acid, 2,3-dihydro-5-methyl-α-[[[1-(2-nitrophenyl)ethoxy]carbonyl]amino]-3-oxo-, (αS)-

Biological Activity

[Description]:

NPEC- caged-(S)-AMPA, a caged neurotransmitter analog, is a NPEC photoprotecting group caged the (S)-AMPA (HY-100815A) to make caged ligands specific for glutamate receptor sub-types. NPEC- caged-(S)-AMPA selectively activates AMPA receptor[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

AMPA Receptor


[References]

[1]. Francisco Palma-Cerda, et al. New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 2012 Sep;63(4):624-34.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
677.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H17N3O8

[ Molecular Weight ]:
379.322

[ Flash Point ]:
363.7±31.5 °C

[ Exact Mass ]:
379.101563

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.605

Related Compounds