Benzyl-PEG2-CH2COOH

Names

[ Name ]:
Benzyl-PEG2-CH2COOH

[Synonym ]:
Acetic acid, 2-[2-[2-(phenylmethoxy)ethoxy]ethoxy]-
10-phenyl-3,6,9-trioxadecanoic acid
{2-[2-(Benzyloxy)ethoxy]ethoxy}acetic acid
2-(2-(2-(Benzyloxy)ethoxy)ethoxy)acetic acid

Biological Activity

[Description]:

Benzyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
409.7±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₈O₅

[ Molecular Weight ]:
254.279

[ Flash Point ]:
152.5±18.1 °C

[ Exact Mass ]:
254.115417

[ PSA ]:
64.99000

[ LogP ]:
0.68

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.514

Benzyl-PEG2-CH2COOH

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds