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Benzyl-PEG2-CH2-Boc

Names

[ CAS No. ]:
1643957-26-9

[ Name ]:
Benzyl-PEG2-CH2-Boc

[Synonym ]:
2-Methyl-2-propanyl {2-[2-(benzyloxy)ethoxy]ethoxy}acetate
Acetic acid, 2-[2-[2-(phenylmethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
MFCD28122971

Biological Activity

[Description]:

Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
396.0±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H26O5

[ Molecular Weight ]:
310.385

[ Flash Point ]:
170.7±23.8 °C

[ Exact Mass ]:
310.178009

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.488

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds